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TOP >  学術論文:マスティハ  もくじ > マスティハ・ガムと口腔科学



1.     日本歯科保存学雑誌 53(2), 123-132, 2010-04-30
特定非営利活動法人日本歯科保存学会
 
  音波振動歯ブラシとマスティック配合歯磨剤の慢性歯周炎に対する臨床的・細菌学的効果
Clinical and Microbiological Effects of a Sonic Toothbrush and Mastic Compound Dentifrice on Chronic Periodontitis
 
  渡辺 久,萩原 さつき,和泉 雄一
WATANABE Hisashi,HAGIWARA Satsuki,IZUMI Yuichi
 
  東京医科歯科大学大学院医歯学総合研究科生体硬組織再生学講座歯周病学分野
Periodontology, Department of Hard Tissue Engineering, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
 
 

抄録
マスティックは,コショウボクから採取した樹脂である.慢性歯周炎に対する音波振動歯ブラシ(SB)とマスティック配合歯磨剤(MD)の臨床的・細菌学的効果をRandomized Control Test(RCT)により検討した.慢性歯周炎患者22名を無作為に試験群(SB+MD)11名(男性6名,女性5名,平均年齢:63.2歳)とプラセボ群(SB+マスティック非配合歯磨剤)11名(男性4名,女性7名,平均年齢:55.5歳)に振り分け,4週間モニターを実施した.被験部位は1名当たり3部位とした.Base line,2,4週目に臨床パラメーターによる臨床検査,Base lineと4週目にreal time PCR定量法による細菌検査を実施した.被験細菌はPorphyromonas gingivalis,Aggregatibacter actinomycetemcomitans,Treponema denticola,Tannerella forsythensis,Prevotella intermediaである.被験者の口腔症状には両群間で有意差はなかった.臨床指標のうち,腫脹,発赤,出血,プラーク指数,排膿について,両群ともにBase lineに比べ2週目および4週目で有意な改善がみられた.群間比較では出血の項目で,試験群はプラセボ群に比べて有意に優れていた(p<0.05).改善率でみると,試験群はプラセボ群に比べて,腫脹,出血,プラークの項目で有意に大きかった(p<0.05).細菌については,試験群のみに,Base lineに比べ4週目でP.gingivalisおよびRed Complexについて,総菌数に対する比率が有意に減少した(p<0.01,p<0.05).本研究の結果より,音波振動歯ブラシとマスティック配合歯磨剤が歯周病原性細菌数の抑制を介して,慢性歯周炎の炎症の軽減に有用であることが示唆された.

Abstract

Mastic is a resinous exudate obtained from the stem and main leaves of Pistacia lentiscus. The aim of the present study was to assess the clinical and microbiological effect of a sonic toothbrush (SB) and a mastic-essential-oil compound dentifrice (MD) on chronic periodontitis, in a randomized control trial. Twenty-two volunteers with chronic periodontitis were assigned in random to the two groups; the experimental group (SB+MD): 11 patients (6 males, 5 females, mean age 63.2 years) and the placebo group (SB+non-MD): 11 patients (4 males, 7 females, mean age 55.5 years). Three sites per each were subjected. At the baseline and at 2 and 4 weeks, clinical measurements were performed using clinical parameters. In addition, subgingival plaque was collected at the baseline and at 4 weeks. A quantitative analysis of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Tannerella forsythensis, Prevotella intermedia was carried out using real-time polymerase chain reaction (PCR) procedures. There was no significant difference between the two groups with regard to the clinical conditions at the base line. A significant decrease of inflammation was noted after using a sonic toothbrush and dentifrice for 2 and 4 weeks in both the mastic group and the placebo. As for swelling, bleeding, and plaque accumulation, the mastic group showed a significant improvement compared to the control (p<0.05). A significant suppression of P. gingivalis and red complex in the ratio against total bacteria cell counts after 4 weeks of treatment were observed only in the mastic group (p<0.01, p<0.05, respectively). This study suggests that a sonic toothbrush and a mastic-essential-oil compound dentifrice may be useful for chronic periodontitis.

 

2.       Journal of the Japanese Society of Periodontology, Vol. 43, Issue 13(4) Page 86
日本歯周病学会会誌
 
  Mastic gum Inhibits Bacterial Grow in Oral Cavity  
  Munemoto Fukazawa, Keiso Takahashi, Kazuyuki Watanabe, Hitoshi Motohira, Shigeru Amano, Kuniyasu Ochiai and Takashi Miyata  
  Departments of Periodontology, Microbiology, Meikai University School of Dentistry  
  [Type: Clinical Research]  


3.    Journal of Periodontology, April 2003, Vol.74, No.4, pages 501-505.  
  A Pilot Study on Anti-plaque Effects of Mastic Chewing Gum in the Oral Cavity  
  Keiso Takahashi, Munemoto Fukazawa, Hitoshi Motohira, Kuniyasu Ochiai, Hirofumi Nishikawa, and Takashi Miyata  
  Abstract
Background:
Chemical plaque control is a useful aid in mechanical oral hygiene, and various chemical agents have been evaluated as antiplaque agents. It has been shown that mastic chewing gum has antibacterial effects on Helicobacter pylori. In this study, the antiplaque effect of mastic chewing gum was investigated.
Methods: Twenty dental students who were both systemically and periodontally healthy participated in this study. The effects of mastic gum were assessed from 2 double-blinded, randomized studies. In the first trial, after mechanical toothbrushing, the inhibitory effect of mastic gum on bacteria in saliva following its use was compared to a placebo gum. Saliva samples were collected at the end of 1, 2, 3, and 4 hours; diluted; inoculated onto 10% horse blood chocolate agar plates; and cultured anaerobically at 37°C for 48 hours. The total number of bacterial colonies on each plate was calculated (n = 20). In the second trial, the effects of mastic gum on de novo plaque formation on tooth surfaces and gingival inflammation were evaluated over a 7-day period without mechanical oral hygiene following random use of either mastic or placebo chewing gum. The degree of plaque accumulation and gingival inflammation were compared between the 2 groups (n = 10).
Results: The total number of bacterial colonies was significantly reduced during the 4 hours of chewing mastic gum compared to the placebo gum (P <0.05, Student t test). The mastic group showed a significantly reduced plaque index (2.69 ± 0.29 versus 3.15 ± 0.24; P = 0.001, Student t test) and gingival index (0.44 ± 0.15 versus 0.66 ± 0.23, P = 0.021, Student t test) compared to the placebo group.
Conclusion: These results suggest that mastic chewing gum is a useful antiplaque agent in reducing the bacterial growth in saliva and plaque formation on teeth.
 


4.    薬理と治療 2010, 巻:38 号:10 頁:915-925  
 
歯周炎に対する音波振動歯ブラシ使用下でのマスティックエッセンシャルオイル配合歯磨剤の有用性に関する二重盲検無作為化比較試験
 
  WATANABE Hisashi ; HAGIWARA Satsuki ; FUKUDA Motohisa ; YUICHI Izumi ; TAMURA Noriko ; SUZUKI Masamitsu ; KAWASAKI Daisuke ; FUKAHORI Masahiro ;  
  東京医歯大 大学院医歯学総合研究科 生体硬組織再生学 歯周病学分野 他  
  Abstract
Mastic is a resinous exudate obtained from stem and main leaves of Pistacia lentiscus. The aim of the present study was to assess clinical and microbiological effect of mastic-essential-oil compound dentifrice (MD) on chronic periodontitis under using sonic toothbrush (SB), in a randomized control trial. Twenty two volunteers with chronic periodontitis were assigned in random to two groups ; the experimental group (SB+MD): 11 patients (6 males, 5 females, mean age 63.2 years) and the placebo group (SB+non-MD): 11 patients (4 males, 7 females, mean age 55.5 years). 3 sites per each were subjected. At baseline and at 2, 4 and 12 weeks, clinical measurements were performed using clinical parameters. In addition, subgingival plaque was collected at baseline and at 4 and 12 weeks. A quantitative analysis of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Tannerella forsythia, Prevotella intermedia were carried out using real-time polymerase chain reaction (PCR) procedures. There was no significant difference between two groups as to the clinical conditions at base line. Significant decreased inflammation was noted after using sonic toothbrush and dentifrice for 2, 4 and 12 weeks in both mastic group and placebo. As to swelling, bleeding, redness of gingiva and plaque accumulation, mastic group showed a significant improvement compared to the control (p<0.05). A significant suppression of P. gingivalis and red complex in the ratio against total bacteria cell counts after 4 week treatment, and P. gingivalis and P. inter-media after 12 week treatment were observed in only mastic group (P<0.05). In addition, the test group was significantly superior to the placebo as to the suppression of P. gingivalis at 12 weeks after treatment (P<0.05). This study suggests that sonic toothbrush and dentifrice may be useful for chronic periodontitis, and the useful effect for chronic periodontitis may cause the anti periodontal-pathogen by mastic-essential-oil.
 


5.     日本歯科保存学雑誌
THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 47(6), 897-905, 2004-12-31
 
  マスティックエッセンシャルオイル配合歯磨剤の臨床的・細菌学的研究
Clinical and Microbiological Evaluation of Mastic-essential-oil Compound Dentifrice
 
  渡辺 久a,長谷川奈美a,石川 烈a,櫻井 英知b,深堀 勝博b
WATANABE Hisashi,HASEGAWA Nami,ISHIKAWA Isao,SAKURAI Hidetomo,FUKAHORI Masahiro
 
  a 東京医科歯科大学大学院医歯学総合研究科生体硬組織再生学講座 歯周病学分野
a Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
b ゼリア新薬工業株式会社 製品開発部
b Zeria Pharmaceutical Co., LTD. CHC Products Development
 

6.    In Vivo. 2009 Mar-Apr;23(2):215-23.  
  Selective antibacterial and apoptosis-modulating activities of mastic.  
  Sakagami H, Kishino K, Kobayashi M, Hashimoto K, Iida S, Shimetani A, Nakamura Y, Takahashi K, Ikarashi T, Fukamachi H, Satoh K, Nakashima H, Shimizu T, Takeda K, Watanabe S, Nakamura W.  
  Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan.  
  Abstract
Mastic is a resinous exudate obtained from the stem and the main leaves of Pistacia lentiscus. We have reported the antiplaque effect of mastic-containing chewing gum on the oral cavity. We hypothesize that mastic may be a multifunctional food which has some beneficial pharmaceutical properties. The aim of this study was to assess the biological activity of solid and liquid types of mastic by cytotoxicity against fibroblasts, radical-scavenging activities and inhibitory effect on cell death of oral polymorphonuclear leukocytes (OPMNs). Mastic showed selective antibacterial action against Porphyromonas gingivalis and Prevotella melaninogenica, but no anti-HIV activity. Among a total of thirteen human cell types, promyelocytic leukemia HL-60 was the most sensitive to the cytotoxicity of mastic, followed by myeloblastic leukemia (ML-1, KG-1), erythroleukemia (K-562), oral squamous cell carcinoma (HSC-2, HSC-3, HSC-4), hepatocellular carcinoma (HepG2), glioblastoma (T98G, U87MG) and normal oral cells (gingival fibroblast, pulp cell, periodontal ligament fibroblast, most resistant). Mastic did not induce the differentiation of myelogenous leukemic cells into maturing cells with higher nitroblue tetrazolium-reducing activity, but induced apoptotic cell death, characterized by internucleosomal DNA fragmentation, caspase-3 activation and a decline in the intracellular concentration of putrescine. The cytotoxicity of mastic against leukemic cells did not diminish during its storage. On the other hand, mastic inhibited the spontaneous apoptosis of OPMNs. Mastic showed hydroxyl radical-scavenging activity. The selective antibacterial and apoptosis-modulating activity of mastic suggests its possible beneficial effects on oral health.
 


7.     日本歯周病学会会誌 43(秋季特別号), 98, 2001-09-30  
  A-15-15 : 05 マスティックオイルによる口臭抑制効果
Effect of Mastic Oil to Suppression of Halitosis
 
  大室 博正a,辻上 弘a,弓場 光泰a,前堀 隆光a,菅谷 彰a,出口 眞二a,高橋 裕介b,梅本 俊夫b
Omuro Hiromasa,Tsujigami Hiroshi,Yumiba Mitsuyasu,Sugaya Akira,Deguchi Shinji,Takahashi Yuusuke,Umemoto Toshio
 
  a 神奈川歯科大学歯周病学講座
a Department of Periodontology, Kanagawa Dental College
b 神奈川歯科大学口腔細菌学講座
b Department of Oral Microbiology, Kanagawa Dental College
 


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