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Journal of Ethnopharmacology, Vol. 15, Issue 13, March 1986, Pages 271-278 |
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Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity |
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Mansoor S. Al-Said, A. M. Ageel, N. S. Parmarand* M. Tariq |
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Departments of Pharmacology & Pharmacognosy and the Research Centre, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia |
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Abstract
The effect of mastic, a concrete resinous exudate obtained from the stem of the tree Pistacia lentiscus, has been studied on experimentallyinduced gastric and duodenal ulcers in rats. Mastic at an oral dose of 500 mg/kg produced a significant reduction in the intensity of gastric mucosal damage induced by pyloric ligation, aspirin, phenylbutazone, reserpine and restraint + cold stress. It produced a significant decrease of free acidity in 6-h pylorus-ligated rats and a marked cytoprotective effect against 50% ethanol in rats, which could be reversed by prior treatment with indomethacin. The protective effect was not seen when it was given intraperitoneally in phenylbutazone and restraint + cold stress models. The reduction in the intensity of ulceration in cysteamine-induced duodenal ulcers was not found to be statistically significant in mastic-pretreated rats. The results suggest that mild antisecretory and a localized adaptive cytoprotectant action may be responsible for its anti-ulcer activity. These observations support the results of an earlier study on the clinical effectiveness of mastic in the therapy of duodenal ulcer.
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2. |
The American Journal of Gastroenterology, Vol. 96, Issue 9, Supplement 1, September 2001, Page S49 |
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Bactericidal activity of Pistacia lentiscus gum mastic against Helicobacter pylori |
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Serafino G. Bona1, Letizia Bono2, Laura Daghetta3 and Pietro Marone 2* |
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1Ambulatorio di Gastroenterologia e Endoscopia Digestiva, VIGEVANO, (PV), Italy; 2Laboratorio di Batteriologia e Micologia, IRCCS S. Matteo, PAVIA, (PV), Italy; and 3Laboratorio Analisi S. Ambrogio, VIGEVANO, (PV), Italy |
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3. |
New England Journal of Medicine, Vol. 339, Issue 26, Dec. 24, 1998 p. 1946 |
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Mastic Gum Kills Helicobacter pylori |
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Farhad U. Huwez, L; Debbie Thirlwell; Alan Cockayne; Dlawer A.A. Ala'Aldeen |
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Barnet General Hospital, Barnet, Herts EN5 3DJ, United Kingdom
University Hospital, Nottingham NG7 2UH, United Kingdom |
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Abstract
Even low doses of mastic gum - 1 g per day for two weeks - can cure peptic ulcers very rapidly, but the mechanism responsible has not been clear. We have found that mastic is active against Helicobacter pylori, which could explain its therapeutic effect in patients with peptic ulcers.
[Type: Clinical Research] |
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4. |
South Korea Society of Gastroenterology |
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Effects of Mastic Gum on Helicobacter pylori Gastritis |
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Im-hwan Roh, Seung-woo Nam, Na-? Myung, Jung-taek Kim, Ji-hun Shin |
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Internal Medicine, Pathology, Surgery and Digestive System Laboratory,
College of Medicine, Dan-kook University |
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5. |
World J Gastroenterology 2007, 13(5):748-753 |
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Chios mastic treatment of patients with active Crohn’s disease. |
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Andriana C. Kaliora, Maria G Stathopoulou, John K Triantafillidis, G Dedousis, N.K. Andrikopoylos |
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Department of Gastroenterology, Saint Panteleimon General State Hospital, Nicea, Athens, Greece. |
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Abstract
To evaluate the effectiveness of mastic administration on the clinical course and plasma inflammatory mediators of patients with active Crohn’s disease (CD). The pilot study was conducted in patients with established mild to moderately active CD, attending the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps. All patients successfully completed the protocol. The results suggests that significantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately active CD. Further double-blind, placebo-controlled studies in a large number of patients are required to clarify the role of this natural product in the treatment of patients with CD. |
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6. |
Phytomedicine 2010 Vol.17 pages 296-299 |
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The effect of mastic gum on Helicobacter pylori: A randomized pilot study |
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K.J. Dabos , E. Sfika, L.J. Vlatta, G. Giannikopoulos |
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Department of Gastroenterology, Chios General Hospital Skylitsion, Helenas Venizalou 2, 82100 Chios, Greece |
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Our aim was to study the effect of pure mastic gum on Helicobacter pylori (H. pylori) eradication in patients suffering from an H. pylori infection. Fifty two patients were randomized to receive either 350mg three times a day (tid) of pure mastic gum for 14 days (Group A), or 1,05 g tid of pure mastic gum (Group B) for 14 days, or pantoprazole 20mg twice a day (bd) plus pure mastic gum 350mg tid for 14 days (Group C) or pantoprazole 20mg bd plus amoxicillin 1 g bd plus clarithromycin 500mg bd for 10 days (Group D). All patients harboured H. pylori before entering the study and that was confirmed by a 13C urea breath test (UBT). H. pylori eradication was tested by a UBT 5 weeks after completion of the eradication regime. Eradication of H. pylori was confirmed in 4/13 patients in Group A and in 5/13 in Grour B. No patient in Group C achieved eradication whereas 10/13 patients in Group D had a negative UBT. There were no statistically significant differences in mean UBT values in Groups A, B, C although there was a trend in Group A (p=0.08) and in Group B (p=0.064). The difference was significant in Group D (p=0.01). All patients tolerated mastic gum well and no serious adverse events were reported. Mastic gum has bactericidal activity on H. pylori in vivo. |
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7. |
Journal of Ethnopharmacology vol.127 (2010) pages 205-209 |
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Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial |
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Konstantinos J. Dabosa,∗, Ekaterini Sfikaa, Lisa J. Vlattaa, Despoina Frantzia, Georgios I. Amygdalosb, Georgios Giannikopoulosc |
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a Department of Gastroenterology, Chios General Hospital Skylitsion, Chios, Greece
b Department of General and Abdominal Surgery, Chios General Hospital Skylitsion, Chios, Greece
c Department of Internal Medicine, Chios General Hospital Skylitsion, Chios, Greece |
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Background: Herbal remedies are increasingly popular for the treatment of functional dyspepsia. Chios mastic gum is a resinous exudate from the stem of Pistacia lentiscus var. chia. It is a traditional natural remedy used throughout the eastern Mediterranean. The aim of this study was to assess the efficacy of Chios masticgumin patients with functional dyspepsia.
Methods: One hundred and forty eight patients fulfilling Rome II criteria for functional dyspepsia were randomly assigned to receive either Chios mastic gum 350mg three times daily or placebo. After 3 weeks of treatment the change from baseline in the severity of symptoms of functional dyspepsia was assessed using the Hong Kong index of dyspepsia. Patients’ global assessment of efficacy was also evaluated.
Results: The symptom score after treatment was significantly lower in the Chios mastic gum than in the placebo group ((14.78±1.78) vs (19.96±1.83)) (p < 0.05). There was a marked improvement of symptoms in 40% of patients receiving placebo and in 77% of patients receiving Chios masticgum(p < 0.02). Individual symptoms that showed significant improvement with Chios mastic gum were: stomach pain in general, stomach pain when anxious, dull ache in the upper abdomen and heartburn (<0.05 for all four symptoms).
Conclusion: Chios mastic gum significantly improves symptoms in patients with functional dyspepsia compared to placebo. |
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